Jeffrey G. Linger is a research scientist in the Applied Biology group within NREL's Renewable Resources and Enabling Sciences Center. Jeffrey joined NREL in 2007 as a postdoctoral fellow studying the production of biofuels. Specifically, Jeffrey uses molecular biology techniques to assess the feasibility of converting the microorganism Zymomonas mobilis into a consolidated bioprocessing organism through the expression and extracellular secretion of cellulolytic enzymes. Jeffrey's current research focuses on the metabolic engineering of Z. mobilis for use in biofuels production.

Research Interests

Biomass to biofuels conversion

Microbial strain development

Metabolic engineering

Fundamental molecular biology and genetics

Education

Ph.D., Biochemistry and Molecular Genetics, University of Colorado School of Medicine

B.S., Environmental, Population, and Organismic Biology, University of Colorado at Boulder

Featured Work

Heterologous Expression and Extracellular Secretion of Cellulolytic Enzymes in Zymomonas mobilis, Applied and Environmental Microbiology (2010)

FACT and the Proteasome Promote Promoter Chromatin Disassembly and Transcriptional Initiation, Journal of Biological Chemistry (2009)

Acetylated Lysine 56 on Histone H3 Drives Chromatin Assembly after Repair and Signals for the Completion of Repair, Cell (2009)

Chromatin Disassembly from the PHO5 Promoter is Essential for the Recruitment of the General Transcription Machinery and Coactivators, Molecular and Cellular Biology (2007)

Chromatin Disassembly and Reassembly During DNA Repair, Mutation Research (2007)

Global Replication-Independent Histone H4 Exchange in Budding Yeast, Eukaryotic Cell (2006)

Dominant Mutants of the Saccharomyces cerevisiae ASF1 Histone Chaperone Bypass the Need for CAF-1 in Transcriptional Silencing by Altering Histone and Sir Protein Recruitment, Genetics (2006)

The Yeast Histone Chaperone Chromatin Assembly Factor 1 Protects Against Double-Strand DNA-Damaging Agents, Genetics (2005)

Activation of the DNA Damage Checkpoint in Yeast Lacking the Histone Chaperone Anti-Silencing Function 1, Molecular and Cellular Biology (2004)

View all NREL Publications for Jeffery G. Linger.

Patents

Extracellular Secretion of Recombinant Proteins, U.S. Patent No. 8,785,159 (2014)