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Photo of Nicholas J. Nagle

Nicholas Nagle

Researcher IV-Chemical Engineering | 303-384-6184

Research Interests

Nick is interested in understanding how advanced feedstocks perform in a biorefinery setting, assessing their physical and chemical properties, sugar release, and impact on lignin upgrading post conversion. As feedstocks rapidly evolve into new formats, such as densified and blended materials, he finds that evaluating the impact on the bioconversion processes, fermentation, and process scale-up, is both exciting and challenging.


  • B.S., Microbiology, Colorado State University

  • M.S., Environmental Engineering, Colorado School of Mines

Professional Experience

Nick has more than 25 years of experience in the field of biomass conversion via anaerobic digestion, growth of microalgae, pretreatment, and enzymatic hydrolysis of biomass for bioethanol productions. This breadth of work has been conducted at bench to pilot plant to production scale. Nick has designed, planned, and executed experimental tasks at the project level leading to understanding the biomass recalcitrance to enzymatic and thermochemical conversion. His work has been conducted with a number of collaborators spanning, the U.S. Department of Agriculture, U.S. Department of Energy laboratories, universities, and industrial partners. Nick is skilled at technical organization, project management, and project presentation.

Featured Publications

  1. "Impact of biomass processing, blending and densification, on bioconversion and lignin upgrading from herbaceous and woody feedstocks," (forthcoming)

  2. "Evaluating the pelletization of 'pure' and blended lignocellulosic biomass feedstocks," Fuel Processing Technology (2015)

  3. "Acid-catalyzed algal biomass pretreatment for integrated lipid and carbohydrate-based biofuels production," Green Chemistry (2015)

  4. "Enzymatic Conversion of Xylan Residues from Dilute Acid Pretreated Corn Stover," Applied Biochemistry and Biotechnology (2012)

  5. "Feedstock handling and processing effects on biochemical conversion to biofuels," BIOFPR (2010)

  6. "Extraction of bio-oils from microalgae: a review," Journal of Separation and Purification Reviews (2009)

  7. "Fermentation of 'Quick Fiber' Produced from a Modified Corn-Milling Process into Ethanol and Recovery of Corn Fiber," Applied Biochemistry and Biotechnology (2004)

  8. "Conversion of Distiller's Grain into Fuel Alcohol and a Higher-Value Animal Feed by Dilute-Acid Pretreatment," Applied Biochemistry and Biotechnology (2004)

  9. "Efficacy of a Hot Washing Process for Pretreated Yellow Poplar to Enhance Bioethanol Production," Biotechnology Progress (2002)

  10. "A process economic approach to develop a dilute acid cellulose hydrolysis process to produce ethanol from biomass," Applied Biochemistry and Biotechnology (1999)

View all NREL Publications for Nick Nagle.