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Gayle Bentley

Gayle Bentley

Postdoctoral Researcher- Metabolic Engineering and Synthetic Biology

| 303-275-4868

Research Interests

  • Metabolic engineering of Pseudomonas putida KT2440 for the production of muconate

  • Understanding the contribution of stochasticity to variable production phenotypes

  • Designing genetic circuits

  • Fatty acid biosynthesis for the production of value-added chemicals and fuels, specifically branched-chain fatty acids and their derivatives

  • Development of novel strain engineering technologies

Areas of Expertise

  • Metabolic engineering

  • Synthetic biology

  • Molecular microbiology

  • Fatty acid biosynthesis

Education

  • Ph.D., Molecular Microbiology and Microbial Pathogenesis, Washington University in St. Louis, 2016

  • M.P.H., Epidemiology, University of Arizona, 2010

  • B.S., Microbiology, University of Arizona, 2008

Professional Experience

  • Affiliate Faculty Member, Colorado School of Mines, Department of Chemistry, 2018-present

Patents

  1. “Engineered Microorganisms for the Production of Intermediates and Their Final Products,” U.S. Patent Application No. 62/664,445 (2018)
  2. "Host Cells and Methods for Producing Fatty Acid-Derivatives with High Branched-Chain Percentage," U.S. Patent No. 2017106747A1 (2016)

Featured Publications

  1. "Membrane Permeability of Terpenoids Explored with Molecular Simulation," The Journal of Physical Chemistry (2018)
  2. "Modular pathway engineering for the microbial production of branched-chain fatty alcohols," Biotechnology and Bioengineering (2017)
  3. "Engineering Escherichia coli to produce branched-chain fatty acids in high percentages," Metabolic Engineering (2016)

  4.  "Enhanced production of branched-chain fatty acids by replacing β-ketoacyl-(acyl-carrier-protein) synthase III (FabH)," Biotechnology and Bioengineering (2015) 

  5.  "Pediatric fecal microbiota harbor diverse and novel antibiotic resistance genes," PLoS One (2013)