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Photo of Deanne W. Sammond

Deanne Sammond

Researcher III-Biological Science

Deanne.Sammond@nrel.gov | 303-384-6240

Research Interests

  • Enhancing the conversion of biomass to fuel by improving the function of cellulases

  • Consolidated bioprocessing—engineering thermophilic bacteria to produce ethanol


Areas of Expertise

  • Rational protein design

  • Protein engineering

  • Protein expression and purification

  • Biophysical characterization of proteins

  • Bioinformatics and structural analysis


Education

  • Ph.D., Department of Biochemistry and Biophysics, University of North Carolina, Laboratory of Dr. Brian Kuhlman, 2002–2008

  • B.M., Department of Music, University of Colorado, Studio of Dr. Alvin Chow, 19911995


Professional Experience

  • Currently serving on the Executive Board for the RosettaCommons

  • Organizer of the Winter Rosetta Conference, 2015

  • Co-chair for the Poster Session, Society for Industrial Microbiology and Biotechnology, 2015

  • Served on thesis committee for Elizabeth Eskow, graduate student in computer science at the University of Colorado (Ph.D. awarded in 2013)

  • U.S. Department of Energy (DOE) Office of Science Graduate Student Research (SCGSR) Program mentor for Carolyn Haarmeyer, graduate student in chemical engineering at Michigan State University (DOE SCGSR fellowship awarded for 2015)

  • Postdoctoral Researcher, University of Colorado, Department of Chemistry and Biochemistry, Laboratory of Dr. Hubert Yin, 20082011


Featured Publications

  1. "Predicting Enzyme Adsorption to Lignin Films by Calculating Enzyme Surface Hydrophobicity," Journal of Biological Chemistry (2014)

Illustration "A" is on the left and shows two grey globules; the one on the top has more defined spheres as part of the globule and are colored red, orange, blue, and grey; the bottom grey globule is less defined and has orange, cloudy spheres and a dark grey ribbon going through it. Chart "B" is to the right with an x-axis labeled "Hydrophobic Patch Score" and a y-axis labeled "Total Adsorbed Mass." The chart shows a diagonal dotted line going up from left to right with several dots of multiple colors.

  1. "Cellulase Linkers Are Optimized Based on Domain Type and Function: Insights from Sequence Analysis, Biophysical Measurements, and Molecular Simulation," PLOS One (2012)

Illustration in four quadrants. The upper left figure shows a large, grey, spherical globule with grey globs leading right to a smaller grey, spherical globule; there are blue and yellow globs on top of the grey; this sits on top of several bars of green globs, one strand that reaches into the large grey spherical globule; this is labeled underneath with

  1. "Computational Design of the Sequence and Structure of a Protein-Binding Peptide," Journal of the American Chemical Society (2011)

    Illustrations showing red and blue globs with green ribbons on a light grey, indistinct globular background. The top figure (labeled "a") has very thing green ribbons; the bottom figure (labeled "b") has thicker green ribbons that are more helical in shape.

Additional Publications

  1. "Comparing Residue Clusters from Thermophilic and Mesophilic Enzymes Reveals Adaptive Mechanisms," PLOS One (2016)
  2. "The Catalytic Mechanism and Low pH Optimum of Caldicellulosiruptor bescii Family 3 Pectate Lyase," Acta Cryst. D (2015)
  3. "Computationally Designed Peptide Inhibitors of the Ubiquitin E3 Ligase SCFFbx4," ChemBioChem (2013)
  4. "Transmembrane Peptides Used to Investigate the Homo-Oligomeric Interface and Binding Hot-Spot of Latent Membrane Protein 1," Biopolymers (2011)
  5. "Structural Determinants of Affinity Enhancement between GoLoco Motifs and G-protein Alpha Subunit Mutants," Journal of Biological Chemistry (2011)
  6. "Computational Design of Second-Site Suppressor Mutations at Protein-Protein Interfaces," Proteins (2010)
  7. "A Peptide Antagonist of the TLR4-MD2 Interaction," ChemBioChem (2009)
  8. "Computer-Based Design of Protein-Protein Interactions," Journal of Biomolecular Structure & Dynamics (2009)
  9. "Structure-Based Protocol for Identifying Mutations that Enhance Protein-Protein Binding Affinities," Journal of Molecular Biology (2007)
  10. "Molecular Dynamics Simulation of Amyloid β Dimer Formation," Biophysical Journal (2004)
  11. "Normal Metabolism but Different Physical Properties of Myelin from Mice Deficient in Proteolipid Protein," Journal of Neurosciences Research (2003)
  12. "Alterations in Metabolism and Gene Expression in Brain Regions During Cuprizone-Induced Demyelination and Remyelination," Journal of Neurochemistry (2002)
  13. "Cerebroside Synthesis as a Measure of the Rate of Remyelination Following Cuprizone-Induced Demyelination in Brain," Journal of Neurochemistry (2001)

View all NREL Publications for Deanne W. Sammond.


Awards and Honors

  • National Academies Keck Futures Initiative, co-PI with Hubert Yin, Joshua Ferreira, and Clifford Wang (2010)

  • Bioinformatics and Computational Biology Training Grant, University of North Carolina at Chapel Hill (2002)

  • Molecular and Cellular Biophysics Training Grant, University of North Carolina at Chapel Hill (2002)