Michael Resch holds a Ph.D. in Biochemistry and Molecular Biology from Colorado State University. His dissertation work focused on the biophysical and structural properties of nucleosomes and chromatin arrays in vitro in the laboratories of Dr. Karolin Luger and Dr. Jeffery Hansen at Colorado State University.
Dr. Resch's NREL career began in 2008 as a postdoctoral researcher working on cellulase and hemicellulase enzyme characterization working on projects funded by the Department of Energy through the BioEnergy Science Center (BESC) and the Bioenergy Technologies Office (BETO). In early 2011, he was hired as a research scientist and has focused on comparing the saccharification mechanisms between free fungal and complexed bacterial enzyme systems. He uses protein crystallography, small-angle X-ray scattering, analytical ultracentrifugation, FPLC, HPLC, TEM, SEM, and poly-acrylamide gel electrophoresis to characterize the biophysical nature of these systems. The ultimate goal of these studies is to improve the hydrolysis efficiency of cellulase and hemicellulase enzyme digestion of biomass. This work will help NREL lower the industrial cost of lignocellulosic enzyme conversion of biomass to sugars for biofuel production.
Another source of terrestrial carbon in biomass is in the form of lignin. Lignin has historically been used for heat and power in an industrial setting. Dr. Resch is also involved in investigating biological lignin depolymerization with the ultimate goal of converting lignin into value added fuels or chemicals.
In 2014 Dr. Resch became the Section Supervisor of the Bioprocess Research Group in NREL's National Bioenergy Center. The researchers in this diverse group are involved with microbial development of photobiological and fermentation applications.
Accepted Peer-Reviewed Publications
- D.W. Sammond, J.M. Yarbrough, E. Mansfield, Y.J. Bomble, S.E. Hobdey, S.R. Decker, L.E. Taylor, M.G. Resch, J.J. Bozell, M.E. Himmel, T.B. Vinzant, M.F. Crowley. "Predicting Enzyme Absorption to Lignin Films by Calculating Enzyme Surface Hydrophobicity." (2014) J. Biol Chem.
- M.G. Resch, B.S. Donohoe, P.N. Ciesielski, J.E. Nill, L.Magnusson, M.E. Himmel, A. Mittal, R. Katahira, M.J. Biddy, G.T. Beckham "Clean fractionation pretreatment reduces enzyme loadings for biomass saccharification and reveals the mechanism of free and cellulosomal enzyme synergy." (2014) ACS Sustainable Chemistry and Engineering.
- L. Chen, M.R. Drake, M.G. Resch, E.R. Greene, M.E. Himmel, P.K. Chaffey, G.T. Beckham, Z.Tan. "Specificity of O-Glycosylation in Enhancing the Stability and Cellulose Binding Affinity of Family 1 Carbohydrate-Binding Modules." (2014) Proc. Natl. Acad. Sci. USA.
- P.N. Ciesielski, M.G. Resch, B. Hewetson, J.P. Killgore, A. Curtin, N. Anderson, A.N. Chiaramonti, D.C. Hurley, A. Sanders, M.E. Himmel, C. Chapple, N. Mosier, B.S. Donohoe. "Engineering plant cell walls: tuning lignin monomer composition for deconstructable biofuel feedstocks or resilient biomaterials." (2014) Green Chemistry.
- R. Burnecky, M. Alahuhta, Q. Xu, B. S. Donohoe, M.F. Crowley, M.G. Resch, I.A. Kataeva, S. Yang, M.W. Adams, V.V. Lunin, M.E. Himmel, Y.J. Bomble. "Revealing Nature's Cellulase Diversity: The Hyperactive CelA from Caldicellulosiriptor Bescii." (2014) Science.
- R. Brunecky, B. S. Donohoe, M. J. Selig, H. Wei, M.G. Resch, and M. E. Himmel. "Basic biological research relevant to feedstock conversion." (2014) Science Publishers, Book Chapter, Compendium of Bioenergy Crops.
- C.M. Payne, M.G. Resch, L. Chen, M.F. Crowley, M.E. Himmel, L.E. Taylor II, M. Sandgren, J. Ståhlberg, I. Stal, Z. Tan, G.T. Beckham. "Glycosylated linkers in multi-modular lignocellulose degrading enzymes dynamically bind to cellulose." (2013) Proc. Natl. Acad. Sci. USA.
- M.G. Resch, B.S. Donohoe, J.O. Baker, S.R. Decker, E.A. Bayer, G.T. Beckham, M.E. Himmel. "Fungal Cellulases and Complexed Cellulosomal Enzymes Exhibit Synergistic Mechanisms in Cellulose Deconstruction." (2013) Energy Env. Sci.
- J. Lee, D.W. Sammond, Z. Fiorini, J.P. Saludes, M.G. Resch, B. Hao, W. Wang, Prof. H. Yin, X. Liu. "Computationally Designed Peptide Inhibitors of the Ubiquitin E3 Ligase SCFFbx4." (2013), Chem. Bio. Chem.
- T. Panchenko, T.C. Sorensen, C.L. Woodcock, Z.Y. Kan, S. Wood, M.G. Resch, K. Luger, S.W. Englander, J.C. Hansen, B.E Black. "Replacement of histone H3 with CENP-A directs global nucleosome array condensation and loosening of nucleosome superhelical termini." (2011). Proc. Natl. Acad. Sci. USA.
- G.T. Beckham, Y.J. Bomble, J.F. Matthews, C.B. Taylor, M.G. Resch, J.M. Yarbrough, S.R. Decker, L. Bu, X. Zhao, C. McCabe, J. Wohlert, M. Bergenstråhle, J.W Brady, W.S. Adney, M.E. Himmel, M.F. Crowley. "The O-glycosylated linker from the Trichoderma reesei Family 7 cellulase is a flexible, disordered protein."(2010) Biophys. J.
- M.G. Resch, S. Watanabe, W. Lilyestrom, N. Clark, J.C. Hansen, C. Peterson, K. Luger."Structural characterization of the H3K56Q nucleosomes and nucleosomal arrays." (2010) Biochim. Biophys. Acta.
- S.J. McBryant, J. Klonoski, T.C. Sorensen, S.S. Norskog, S. Williams, M.G. Resch, J.T. Toombs, S.E. Hobdey, and J.C. Hansen. "Determinants of histone H4 N-terminal domain function during nucleosomal array oligomerization: Roles of amino acid sequence, domain length, and charge density." (2009) J. Biol Chem.
- X. Lu, J.M. Klonoski, M.G. Resch, J.C. Hansen. "In vitro chromatin self-association and its relevance to genome architecture." (2006) Biochem Cell Biol.