Michael T. Guarnieri, Ph.D.
Dr. Michael Guarnieri is a postdoctoral researcher in the National Bioenergy Center's Applied Biology group at the National Renewable Energy Laboratory. He earned his Ph.D. in biochemistry and molecular genetics with a joint degree in biophysics and structural biology at the University of Colorado School of Medicine in 2009, where his research focused upon structural and biophysical characterization of bacterial two-component signaling proteins. Prior to his graduate studies, Dr. Guarnieri did undergraduate research at Brown University, examining viral secretion and virus-host interactions.
Research Interests
Dr. Guarnieri joined NREL in 2009 as a post-doctoral researcher investigating algal biofuels. Specifically, Dr. Guarnieri uses a systems biology approach – utilizing genomics, transcriptomics, metabolomics, and proteomics – to identify and target pathways involved in algal lipid and hydrogen production.
Education
Ph.D., Biochemistry and Molecular Genetics, University of Colorado School of Medicine, 2009
B.A., Honors Chemistry, Rhode Island College, 2003
Peer-Reviewed Publications
- Guarnieri, M.T.; Blagg, B.S.J.; Zhao, R. (2010). "A High-Throughput TNP-ATP Displacement Assay for Screening Inhibitors of ATP-Binding in Bacterial Histidine Kinases." Assay and Drug Development Technologies (Online Ahead of Print November 4, 2010).
- Ito, K.; Qin, Y.; Guarnieri, M.T.; Garcia, T.; Kwei, K.; Mizokami, M.; Zhang, J.; Li, J.; Wands, J.R.; Tong, S. (2010). "Impairment of Hepatitus B Virus Virion Secretion by Single-Amino-Acid Substitutions in the Small Envelope Protein and Rescue by a Novel Glycosylation Site." Journal of Virology (84:24); pp. 12850-12861.
- Pazy, Y.; Motaleb, M.A.; Guarnieri, M.T.; Charon, N.W.; Zhao, R.; Silversmith, R.E. (2010). "Identical Phosphatase Mechanisms Achieved Through Distinct Modes of Binding Phosphoprotein Substrate." Proceedings of the National Academy of Sciences (107:5); pp. 1924-1929.
- Guarnieri, M.T.; Zhang, L.; Shen, J.; Zhao, R. (2008). "The Hsp90 Inhibitor Radicicol Interacts with the ATP-Binding Pocket of Bacterial Sensor Kinase PhoQ." Journal of Molecular Biology (379:1); pp. 82-93. PDB Deposits: 3cgy and 3cgz.
- Zhang, L.; Shen, J.; Guarnieri, M.T.; Heroux, A.; Yang, K.; Zhao, R. (2007). "Crystal Structure of the C-Terminal Domain of Splicing Factor Prp8 Carrying Retinitis Pigmentosa Mutants." Protein Science (16:6); pp. 1024-1031. PDB Deposits: 2p87 and 2p8r.
- Chen, Y.; Guarnieri, M.T.; Vasil, A.I.; Vasil, M.L.; Mant, C.T.; Hodges, R.S. (2007). "Role of Peptide Hydrophobicity in the Mechanism of Action of Alpha-Helical Antimicrobial Peptides." Antimicrobial Agents and Chemotherapy (51:4); pp. 1398-1406.
- Guarnieri, M.; Kim, K.H.; Bang, G.; Li, J.; Zhou, Y.; Tang, X.; Wands, J.; Tong, S. (2006). "Point Mutations Upstream of Hepatitis B Virus Core Gene Affect DNA Replication at the Step of Core Protein Expression." Journal of Virology (80:2); pp. 587-595.
- Bang, G.; Kim, K.H.; Guarnieri, M.; Zoulim, F.; Kawai, S.; Li, J.; Wands, J.; Tong, S. (2005). " Effect of Mutating the Two Cysteines Required for HBe Antigenicity on Hepatitis B Virus DNA Replication and Virion Secretion." Virology (332:1); pp. 216-224.
- Khan, N.; Guarnieri, M.; Ahn, S.H.; Li, J.; Zhou, Y.; Bang, G.; Kim, K.H.; Wands, J.R.; Tong, S. (2004). "Modulation of Hepatitis B Virus Secretion by Naturally Occurring Mutations in the S Gene."
Journal of Virology (78:7); pp. 3262-3270.
Contact Information
Michael Guarnieri, Ph.D.
National Bioenergy Center
National Renewable Energy Laboratory
15013 Denver West Parkway, MS 3323
Golden, CO 80401
Phone: 303-384-7921 / Fax: 303-384-6363
E-mail: Michael.Guarnieri@nrel.gov
