Jeffrey G. Linger, Ph.D.
Jeff Linger is a Research Scientist in the Applied Biology group of the National Bioenergy Center (NBC) within the National Renewable Energy Laboratory (NREL). Dr. Linger joined NREL in 2007 as a post-doctoral fellow studying the production of biofuels. Specifically, Dr. Linger used molecular biology techniques to assess the feasibility of converting the microorganism Zymomonas mobilis into a consolidated bioprocessing organism through the expression and extracellular secretion of cellulolytic enzymes. Dr. Linger's current research focuses on the metabolic engineering of Z. mobilis for use in biofuels production.
Research Interests
- Biomass to biofuels conversion
- Microbial strain development
- Metabolic engineering
- Fundamental molecular biology and genetics
Education
Ph.D., Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, CO, August 2006
B.S., Environmental, Population, and Organismic Biology, University of Colorado at Boulder, December 1998
Patents and Publications
Patents:
Himmel, M. E.; Adney, W. S.; Ding, S. Y.; Linger, J. G.; Van Der Lelie, D.; Taghavi, S. (2010). "Endophytic Enzyme Delivery System." U.S. Provisional Patent Application Number 61297919, Jan 25, 2010.
Linger, J. G.; Darzins, A. (2009). "Extracellular Secretion of Recombinant Proteins." U.S. Provisional Patent Application Number 61264391, Nov 25, 2009.
Peer-reviewed publications:
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Linger, J. G.; Adney, W. S.; Darzins, A. (2010). "Heterologous Expression and Extracellular Secretion of Cellulolytic Enzymes in Zymomonas mobilis." Manuscript in Review.
Ransom, M.; Williams, S. K.; Dechassa, M. L.; Das, C.; Linger, J. G.; Adkins, M.; Liu, C.; Bartholomew, B.; Tyler, J. K. (2009). "FACT and the Proteasome Promote Promoter Chromatin Disassembly and Transcriptional Initiation." Journal of Biological Chemistry (284:35); pp. 23461-23471.
Chen, C. C.; Carson, J. J.; Feser, J.; Tamburini, B.; Zabaronick, S.; Linger, J. G.; Tyler, J. K. (2008). "Acetylated Lysine 56 on Histone H3 Drives Chromatin Assembly after Repair and Signals for the Completion of Repair." Cell (134:2); pp. 231-243.
Adkins, M. W.; Williams, S. K.; Linger, J. G.; Tyler, J. K. (2007). "Chromatin Disassembly from the PHO5 Promoter is Essential for the Recruitment of the General Transcription Machinery and Coactivators." Molecular and Cellular Biology (27:18); pp. 6372-6382.
Linger, J. G.; Tyler, J. K. (2007). "Chromatin Disassembly and Reassembly During DNA Repair." Mutation Research (618:1-2); pp. 52-64.
Linger, J. G.; Tyler, J. K. (2006). "Global Replication-Independent Histone H4 Exchange in Budding Yeast." Eukaryotic Cell (5:10); pp. 1780-1787.
Tamburini, B. A.; Carson, J. J.; Linger, J. G.; Tyler, J. K. (2006). "Dominant Mutants of the Saccharomyces cerevisiae ASF1 Histone Chaperone Bypass the Need for CAF-1 in Transcriptional Silencing by Altering Histone and Sir Protein Recruitment." Genetics (173:2); pp. 599-610.
Linger, J. G.; Tyler, J. K. (2005). "The Yeast Histone Chaperone Chromatin Assembly Factor 1 Protects Against Double-Strand DNA-Damaging Agents." Genetics (171:4); pp. 1513-1522.
Ramey, C. J.; Howar, S.; Adkins, M.; Linger, J. G.; Spicer, J.; Tyler, J. K. (2004). "Activation of the DNA Damage Checkpoint in Yeast Lacking the Histone Chaperone Anti-Silencing Function 1." Molecular and Cellular Biology (24); pp. 10313-10327.
Contact Information
Jeff Linger
National Bioenergy Center
National Renewable Energy Laboratory
15013 Denver West Parkway
Golden, CO 80401
Phone: 303-384-7780
E-mail: Jeffrey.Linger@nrel.gov
