Christopher Chang - Research Scientist

phone: 303-275-3751
email: Christopher.Chang@nrel.gov
At NREL since 2004

Primary Research Interests

Physical modeling of enzymatically controlled chemical and electron transfer reaction
Complex electronic structure, particularly of enzymatic iron-containing cofactors involved in electron transfer
Biomass structure and deconstruction
Thermodynamic/kinetic modeling of metabolism for HPC simulation and optimization

1994	B.S.; Biochemistry; Virginia Tech
1999	Ph.D.; Biochemistry (Enzymology); University of Wisconsin—Madison
2003	International Electron Paramagnetic Resonance Society

2006	Research Scientist, NREL Scientific Computing Center
2004-2006	Research Associate, NREL Scientific Computing Center
2004	Postdoctoral Associate, Prof. Steven Benner, University of Florida. Topic: Molecular evolution of thermostable DNA polymerases.
1999-2004	Postdoctoral Associate, Prof. Nigel Richards, University of Florida. Topics: Cloning and expression of Mn-dependent oxalate decarboxylase; EPR characterization of oxalate decarboxylase; electronic structure of Fe nitrile hydratase and oxalate decarboxylase.

CH Chang, P Graf, DM Alber, K Kim, G Murray, M Posewitz, M Seibert (2008), "Photons, Photosynthesis, and High-Performance Computing: Challenges, Progress, and Promise of Modeling Metabolism in Green Algae," J. Phys. Conf. Ser. 125: 012048.
CH Chang, PW King, ML Ghirardi, K Kim (2007), "Atomic Resolution Modeling of the Ferredoxin:[FeFe] Hydrogenase Complex from Chlamydomonas reinhardtii," Biophys. J. 93: 3034-3045.
MR Nimlos, CH Chang, CJ Curtis, A Miedaner, H Pilath, DL DuBois (2007), "Calculated Hydride Donor Abilities of Five-Coordinate Transition Metal Hydrides [HM(diphosphine)2]+ (M = Ni, Pd, Pt) as a Function of the Bite Angle and Twist Angle of Diphosphine Ligands, Organometallics 27: 2715-2722.
CH Chang, AJ Boone, RJ Bartlett, NGJ Richards (2004), "Toward a Computational Description of Nitrile Hydratase: Studies of the Ground State Bonding and Spin-Dependent Energetics of Mononuclear, Non-Heme Fe(III) Complexes," Inorg. Chem. 43: 458-472.
CH Chang, D Svedruzic, A Ozarowski, L Walker, G Yeagle, RD Britt, A Angerhofer, NGJ Richards (2004), "EPR Spectroscopic Characterization of the Manganese Center and a Free Radical in the Oxalate Decarboxylase Reaction: Identification of a Tyrosyl Radical during Turnover," J. Biol. Chem. 279: 52840-52849.