Christine English - Postdoc
Christine English received her Ph.D. in Biochemistry and Molecular Genetics from the University of Colorado Health Sciences Center in 2006, where she worked under the supervision of Jessica Tyler. Prior to joining NREL, Dr. English designed and executed biochemical and biophysical studies to analyze the structure and function of a protein complex involved in chromatin assembly and disassembly. Specifically, she solved the three-dimensional structure of a three-protein complex using X-ray crystallography, designed structure-based mutations to disrupt the function of this complex, and then analyzed the functional significance of these mutations in vivo and in vitro. Her current research activities include engineering an [FeFe] – hydrogenase that is resistant to O2 inactivation and generating a recombinant, O2-tolerant bacterial construct to be used in algae.
Selected Publications
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Adkins, M.W., Carson, J.J., English, C.M., Ramey, J.C., and Tyler, J. K. (2007), "The histone chaperone anti-silencing function 1 stimulates the acetylation of newly synthesized histone H3 in S-phase," Journal of Biological Chemistry, 12, 1334-40.
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English, C.M., Adkins, M.W., Churchill, M.E.A., and J.K. Tyler (2006), "Structural basis for the histone chaperone activity of Asf1," Cell, 127 (3), 495-508.
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English, C.M., Maluf, N.K., Tripet, B., Churchill, M.E.A., and J.K. Tyler (2005), "The Histone Chaperone Anti-Silencing Function 1 Binds to an H3-H4 Heterodimer: A Two-step Mechanism for the Assembly of the H3-H4 Heterotramer on DNA," Biochemistry, 44, 13673-13682.
Other Team Members
Christine English |
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